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AN EXCLUSIVE INTERVIEW WITH DR. ANGELA CHRISTIANO, THE LEADING RESEARCHER IN HAIR LOSS
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When clumps of her hair began to fall out, Dr Angela Christiano , a scientist at Columbia University in New York,
began a scientific search to find the cure for hair loss. In 1998, Dr. Christiano announced the discovery of a gene that appears to be the 'master switch' for hair growth.
They found the gene after comparing the genes of hairless mice belonging to a mutant breed, and comparing the genes of 11 members of the same family who had lost all their hair. This discovery is a step towards understanding how the hair follicle works and how baldness happens, and may lead to effective treatments becoming available within a few years.
In an exclusive interview with Hair Club, Dr. Christiano details her current lab research and gives us an update in the battle against hair loss.
Q: DOCTOR, CAN YOU TELL US WHAT THE DIFFERENT TYPES OF HAIR LOSS ARE AND WHY IT HAPPENS?
A: DR. CHRISTIANO: The major form of hair loss we see in the clinic is commonly known as male pattern baldness. But, that is a bit of a misnomer, because it affects woman as well. The medical name is Androgenetic Alopecia, which means there is a genetic component and a hormonal competent.
We see it in over 50% of men above the age of 50, and even in about 20% of women. You recognize it on the street as temporal recession of the hairline and some thinning on the top of the head. But, the pattern is different between men and women. There are other types of hair loss that are more rare. Those are what we think of as the somewhat acquired forms, such as Alopecia Areata, where the hair starts to fall out in small circular patches and can eventually progress to cover the whole body. We now speculate that the reason so many people have male pattern baldness is because of the result of maybe 6 or 8 or 10 genes working together under the influence of hormones to bring about the disease.
Q: : HOW DID YOU BECOME INVOLVED IN HAIR LOSS RESEARCH?
A: DR. CHRISTIANO:
My own interest in hair loss began about five years ago.
I had turned thirty and just moved to New York, to begin my own laboratory at Columbia University.
I was going through a very stressful period. Suddenly the hair on my head started to fall out in circles. I had developed Alopecia Areata. I began to take a very strong personal interest in what can cause this disease. Because I work in dermatology I was in a unique position to begin looking into the genes that control hair loss. To my surprise, I found that very little is known about the genetics of hair loss. Our research direction quickly became focused on the genetic basis for hair loss. In the short time we have been working on it we have made a little bit of progress into understanding what makes the hair grow in cycles.
Q: WHAT WILL BE YOUR FOCUS IN THE NEXT 5 YEARS?
A: DR. CHRISTIANO:
The focus of my labs work and others around the world has recently been to identify single genes and understand their individual role in hair growth and cycling.
When we come back to the point of looking at male pattern baldness, as we identify individual genes, maybe those will be some of the targets. Possibly, we can use those as the basis for cures and treatments in the future.
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Q: WE KNOW THAT WE ARE STILL MANY YEARS AWAY FROM DECIPHERING THE HUMAN GENOME AND THE GENES AFFECT MALE PATTERN BALDNESS, AND SUBSEQUENTLY, HOW TO TURN THEM ON AND OFF. WHAT ABOUT CLONING HAIR FOLLICLES?
A: DR. CHRISTIANO: The concept of hair follicle cloning revolves around the ability to remove cells from your own scalp, culture them out in the lab and then reimplant them in the front of the scalp, basically, to create a new hairline. It's one step beyond hair transplantation. Conventionally, in a hair transplant you have the same number of hair follicles, you are just redistributing (hair) from that back of the head to the front. In hair follicle cloning, we can actually think about creating new hair follicles by implanting different cells from the hair follicle into the front of the scalp. Commercially the applications are enormous because it would suggest that starting with a few donor cells, you could culture large numbers of cells and then reimplant them in the front of the scalp, cutting down on the surgical part of hair follicle transplantation.
Q: OPTIMISTICALLY, WHEN DO YOU THINK WE WILL SEE THIS TECHNOLOGY USED?
A: DR. CHRISTIANO:
The technical obstacles for doing hair follicle cloning are enormous. Of course we need to know how to culture the cells, and in terms of reimplanting them, the angle, the repositioning, and the direction of growth of the follicle. The final, most important question is, will the new hairs actually cycle.
This is something that we don't know yet and even though several labs around the country, even around the world, are working on this technology, hair follicle cloning is not yet to the point where anyone can grow a new hair in the laboratory and understand how it cycles. So, there are many many technical points along the way that need to be worked out. In the next five to ten years, it is certainly viable to assume that this technology will be available at least to try in humans.
Q: WHY DO YOU THINK WE, AS A SOCIETY, ARE SO FIXATED ON HAIR?
A: DR. CHRISTIANO:
Because I am a patient who suffers from hair loss in the form of Alopecia Areata, I know first hand that losing your hair is intimately tied to your sense of perception or your sense of esteem. It's the ability to get up in the morning and face the world.
Anything that we associate with appearance or one's well being, I think, is reflected by hair. People don't realize how much hair functions as a social signal, both as a sign of well-being, and as an outward sign to the world. I think, at that level, it is intimately tied to how we feel about ourselves.
Q: HAIR CLUB EMPLOYS MANY PEOPLE WHO ARE DEDICATED TO HELPING THOSE WHO ARE EXPERIENCING THINNING HAIR BY PROVIDING THEM WITH DIFFERENT OPTIONS THAT ARE AVAILABLE TO THE PUBLIC, TODAY.
ALTHOUGH YOU HAVE EXCITING NEWS, IT SEEMS THAT A HAIR LOSS CURE IS STILL BEYOND THE NEXT 10 YEARS. WHAT DO YOU SUGGEST TO PEOPLE WHO ARE CURRENTLY CONCERNED ABOUT LOSING MORE HAIR?
A: DR. CHRISTIANO:
There is a whole arsenal of options people can use, from hair systems to the treatments currently on the market, to alternative therapies and surgical options.
Please know that there are people, like myself, and investigators around the world, working on this problem day and night. I think the goal is to do what you can now to keep what you have and trust that in the future, there will be better things on the market. That will improve this problem going forward.

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Remember, if you're experiencing thinning hair or baldness and are looking into hair replacement systems, hair transplants, minoxidil, Rogaine or Propecia, Hair Club has the answer. If you have any questions concerning your individual needs, and would like more information on how to get started, click the icon to the right and we will connect you to The Hair Club . |
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